Cancer testis antigen vaccination affords long-term protection in a murine model of ovarian cancer.
Sperm protein (Sp17) is an attractive target for ovarian cancer Sifters (OC) vaccines because of its over-expression in primary as well as in metastatic lesions, at all stages of the disease.Our studies suggest that a Sp17-based vaccine can induce an enduring defense against OC development in C57BL/6 mice with ID8 cells, following prophylactic and